Create Your First Project
Start adding your projects to your portfolio. Click on "Manage Projects" to get started
Delivery to complex dynamic environments
Project Type
Preclinical/Translational
We are investigating the development of advanced nanomaterials for targeted delivery within the dynamic and complex environments of the human body. Whether in response to disease, injury, or tissue regeneration, biological tissues and microenvironments are constantly changing. By gaining a deeper understanding of how these tissues evolve over time, we aim to design nanomedicines that can precisely exploit specific therapeutic windows or adapt to the fluctuating conditions, ensuring sustained and efficient delivery. This approach could significantly enhance the effectiveness of treatments by optimizing drug delivery in real-time.
Relevant Publications:
Fernandes LF, Peeyatu C, Dickie BR, Ho YS, Thompson LA, Hernandez N, Lozano N, Kostarelos K*, Kisby T*. Targeting therapeutic nanoparticles to the glioblastoma resection margin by harnessing post-operative spatiotemporal blood-brain barrier disruption. bioRxiv 2025.03. 29.646102
Sharp PS, Stylianou M, Arellano LM, Neves JC, Gravagnuolo AM, Dodd A, Barr K, Lozano N, Kisby T*, Kostarelos K*. Graphene Oxide Nanoscale Platform Enhances the Anti‐Cancer Properties of Bortezomib in Glioblastoma Models. Advanced Healthcare Materials. 2023 Jan;12(3):2201968.
