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Modulating the immune system
Project Type
Basic/Preclinical
Date
April 2023
The immune system plays a major role in the development and progression of many diseases including cancer. By utilising the selective interaction of certain nanomaterials with cells of the immune system we aim to reprogram and direct these toward a less supportive, anti-cancer phenotype. We focus on cells of the wider systemic immune system in addition to those that reside in specific tissues and microenvironments.
Relevant publications:
Stylianou, M., Kisby, T., Despotopoulou, D., Parker, H., Thawley, A., Arashvand, K., Lozano, N., MacDonald, A.S. and Kostarelos, K., 2023. Engineering the glioblastoma microenvironment using TLR7/8 agonist-complexed graphene oxide nanosheets. Cell Reports Physical Science 6(1)
Kisby, T., Yilmazer, A. and Kostarelos, K., 2021. Reasons for success and lessons learnt from nanoscale vaccines against COVID-19. Nature Nanotechnology, 16(8), pp.843-850.
